You've got 10 times as many bacteria in your body as you do human cells, and it shouldn't be surprising that these hitchhikers have a huge effect on health. New research shows that by drugging our gut bacteria we may be able to significantly reduce the incidence of heart disease without changing our diets. Faster, please!
Writing in the journal Cell, researchers from the Cleveland Clinic and UCLA's division of cardiology suggest that disrupting the cascade of events that results in the production of TMAO might also prevent the kinds of fatty buildup in the arteries that leads to heart disease.
They came up with a chemical lookalike to choline, a common chemical compound that plays a key role in processing fatty acids. The lookalike chemical, called DMB, suppresses the first step in the lengthy process of TMAO production. Both in laboratory tests and in mice (where researchers added DMB to the drinking water), they saw that DMB drove down the amount of triethylamine available for liver enzymes to turn into artery-clogging TMAO.
In the study, mice were fed chow that typically doubles fatty buildup in the arteries. Among those mice that got DMB in their water, arterial buildup was significantly reduced; their arteries looked almost like those of normal, healthy mice, the researchers found.