Despite what David Broder and Glenn Reynolds think, I don't see the gerrymandering of House seats as a huge problem. Because of gerrymandering and the 17th Amendment, the House and Senate have essentially reversed roles, with Senate seats turning over more frequently than House seats because state lines can't be redrawn on a whim. So, fine; what's the big deal? Plus, House districts aren't drawn arbitrarily, they're the result of another democratic process, namely state legislatures (whose own districts are also, of course, gerrymandered).
All in all, I'd like to repeal the 17th Amendment and force state legislatures to draw concave House districts, but such things are not high on my list of political priorities. I think ending federal income tax witholding, or eliminating the income tax altogether, would go farther towards reforming and shrinking our government.