Clayton Cramer quotes from some articles about the transgendered deception, as he calls it, and relates some pretty disturbing stories. I'd only like to add that one of the saddest facets of transgenerism is what many transsexuals call the "50% rule": that is, that 50% of transsexuals commit or attempt to commit suicide. There aren't a lot of major studies that I can find, but it's apparently conventional wisdom among transsexuals is supported by some data, as the linked-to site discusses.
Some may be quick to claim that these suicides are caused by a society that refuses to accept the transgendered, but isn't is more likely that a person who would want to undergo irreversible surgery to change his gender is already pretty disturbed? Wouldn't he be better served by counseling than by pandering to his psychosis by validating his self-destructive impulses? One of the tragedies of modern anything-goes morality is that people who really need help are dismissed as simply living an alternative lifestyle; it costs lives and ruins families.
All I know is that I haven't seen a man trapped in a woman's body since before I was born.